منابع مشابه
Asthma heterogeneity and severity
Asthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pathogenesis, prognosis, and treatment of asthma remain incompletely understood. Utilizing measurable c...
متن کاملseverity, and triggers of asthma
The role of heredity in the presence of asthma, severity of the condition, and impact of 12 specific triggers of attacks was investigated. Health surveys containing questions about children's asthma characteristics were completed by 325 families with twin children across the United States. Data for 39 monozygotic twin pairs and 55 same sex dizygotic twin pairs who were between 2 and 20 years of...
متن کاملSeverity of chronic asthma.
How is the severity of chronic asthma best assessed and what are the mechanisms that determine its severity? These two questions are diYcult to answer because, until we understand what asthma is, it is not possible to describe its severity in a given individual. In the shorter Oxford English Dictionary severity in relation to disease is defined as “violence or acuteness of illness” or “grievous...
متن کاملSerum levels of IL-17A increase in Asthma but not in accordance with Serum level of IgE and Asthma Severity
Background and Aims: Recent evidence suggests that T helper (Th) 17 cells are involved in the emergence of asthma. Th17 cells have a key role in inducing inflammation in asthmatic airways thus Interleukin (IL)-17A, the main cytokine of Th17, contributes to airways inflammation. Materials and Methods: We evaluated the level of IL-17A and total immunoglobulin E (IgE) in sera of 100 asthmatic p...
متن کاملVentilation heterogeneity and AHR in asthma
A irway hyperresponsiveness (AHR), inflammation and heterogeneity in airway constriction and ventilation within the airway tree are fundamental features of asthma. Heterogeneity in ventilation is relevant not only because it affects gas exchange efficiency (ventilation/perfusion in asthma), but also because it can theoretically magnify the degree of mechanical obstruction which could affect the...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2016
ISSN: 1939-4551
DOI: 10.1186/s40413-016-0131-2